Joseph Bondy-Denomy, PhD
Professor, Department of Microbiology & Immunology, University of California San Francisco
Joseph Bondy-Denomy is a Professor in the Department of Microbiology & Immunology at the University of California, San Francisco. Prior to coming to UCSF, Joe was a PhD student with Alan Davidson at the University of Toronto, where he studied CRISPR-Cas system and phage-encoded anti-CRISPR proteins.
The Bondy-Denomy lab is broadly interested in understanding mechanisms by which bacteriophages evade bacterial nucleases such as CRISPR-Cas and restriction-modification through mechanisms that include “phage nucleus” compartments, anti-CRISPR enzymes, and phage base modifications. The lab has also works extensively on the immunity and anti-immunity mechanisms of Gabija, CBASS, and Thoeris. Moreover, the group is specifically focused on mechanisms that bacteria have developed to antagonize a specific family of broad host range jumbo phages. A long-term goal is to rationally identify causal barriers to phage success in Pseudomonas aeruginosa clinical isolates and systematically engineer phages to overcome those barriers. Work in the Bondy-Denomy lab has been funded by the NIH, DARPA, the Searle Scholars Program, the Vallee Foundation, and the Innovative Genomics Institute.
